PvP won’t be optional. They want the drama, by incentivising hostility towards other players as opposed to ignoring them and that they want you to have some sense of danger at all times. Although they don’t want the PVP experience to be entirely 'griefy' and that the devs are still tweaking what that means in game.

There are no quest giving NPCs to talk to. Quests are obtained from Holotapes, Terminals, and found environmental objects; robots may give quests. It would seem that a dialogue system will not be featured.

FO76 will be a game as a service, one that constantly evolves as the years go on.

Mods will not happen at launch, but they very much want to have them in the game. They have yet to design the system but they want it to work as mods affect your own 'private world'. Creation Club has not yet been mentioned, however it may return when, and if, they finalise the modding system post-launch.
Edit: Whilst 'private world' could mean custom servers, it could also mean that mods will only affect your world and your own systems data, only visible to you. We could speculate that we may be limited on the types of mods, so no new weapons/armour that provide a benefit; but instead could potentially be a category called 'skins' or 'outfits', like the ones in FO4 that only change your look.

There is no date for the BETA however it was confirmed to only be available to preorders.

VATS is confirmed to be returning, although it is more like a real-time targeting system. It will not slow or freeze time. It seems like it will increase your 'hit chance'/aim assist. As Todd said, his character could be built to be better at vats, so maybe skills for faster lock on, better accuracy, more AP efficiency.

The only thing you lose/gain upon killing another player is caps. You dont get their inventory.

When another player attacks you in 76, a bounty gets put up, if the player getting attacked wins they get a reward. But, if the player attacking initially wins, they get a caps reward as well.
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Ovviamente 11/10, GOTY, Best RPG ever e via così...